Steph Robinson (Jr., Iowa City, Iowa) and Mary Wilkowski (Sr., Savannah, Ga.) scored the opening baskets of the game, but Jess Miller (Sr., Carver, Minn.) tied the game 4-4 with a pair of short jumpers.
Wilkowski and Miller then exchanged shots for the second, and final, tie of the game.
In a low-scoring first half, Wilkowski led the charge with 10 points, as the Pipers led 28-18 at the break. Miller led Saint Mary's with eight points in the opening 20 minutes of play.
The Pipers maintained a six-to-nine point cushion in the second half until Saint Mary's began to chip away at Hamline's lead after the seven-minute mark.
Down by nine, 41-32, at 6:43, Emily DeWitt (Jr., Lino Lakes, Minn.) drained a three to cut their deficit to six. Kim Kaminski (Sr., Milwaukee, Wis.) then made a pair of free throws to pull the Cardinals to within four.
That was the closest that Saint Mary's had been to the Pipers on the scoreboard since the opening five minutes of the game.
Once again Wilkowski and Miller exchanged baskets, keeping the Hamline lead at four, 43-39, with 3:28 to play.
Nikki Klinck (Sr., Hibbing, Minn.) once gain gave Hamline a six-point advantage with a jumper less than a minute later, and Hamline controlled from there.
As Saint Mary's fouled in the final 90 seconds, the Pipers were sent to the line for 14 free throws. They drained 10 of them.
Wilkowski led the Piper scoring with 19 points while pulling down a game-high eight rebounds. She also tallied three blocks and two steals in the game.
Robinson added 10 points and four assists while a trio of additional Pipers scored seven or more points.
Saint Mary's was led by 22 points from Miller. DeWitt added eight points.
Hamline improves to 5-8, 4-6 MIAC while the Cardinals are now 7-5, 5-4 MIAC. The Pipers will hit the road on Monday, January 17, to play a 3:00 p.m. game at St. Thomas.