Larsen entered the match needing just five digs to break the previous career record of 1,792. She tallied 12 in the match.
The Pipers lost by set scores of 25-14, 25-18, 31-29.
The Cardinals used five kills to take an early 6-1 lead in the opening set and kept control of the set from there.
In the second set, Hamline took an early lead, going up 5-2. The Cardinals then took the next three points to even the score. The score was knotted again at 6-6 and 8-8, but Saint Mary's took the next three points for the 11-8 advantage.
Saint Mary's would go on to remain in control to take a 2-0 set lead.
Hamline once again took an early lead as they started the third set. Larsen opened the set with a service ace and the Pipers won the first four points.
Hamline stayed ahead, at one point building a 15-8 advantage as Sam Greeney-Hamlin (Fy., St. Cloud, Minn.) had a pair of kills while up 11-8.
The Pipers had five set points while up 24-19, but the Cardinals began their rally, preventing a fourth set by winning six points in a row.
The two teams tied up the set at every point up until the Pipers had a 29-28 lead. Saint Mary's then strung together three points to win the set, and the match.
Greeney-Hamlin and Molly Schroeder (Sr., Buffalo, Minn.) each had eight kills to lead the Pipers.
Hamline is now 8-9, 1-3 MIAC. Saint Mary's is 10-3, 3-1 MIAC. The Pipers will return to Hutton Arena on Friday, October 1, as they host a non-conference triangular. Hamline plays Buena Vista at 4:00 p.m. and then Carleton at 8:00 p.m. Carleton and Buena Vista will play each other at 6:00 p.m.